engineering services

Instrumentation and Hardware Solutions

We’ll help you optimize your process through efficient and reliable instrumentation that meets your needs today and in the future.

AES provides instrumentation and hardware solutions from specification to design and installation, across both upstream and downstream workflows. If our standard equipment configurations do not meet your exact needs, our team of engineers will custom design and fabricate a solution that matches your requirements. 

All installation, testing and qualification with software is conducted by process and equipment engineers. Our engineering team will also provide support during the initial stages of post-release use, ensuring a seamless transition and comprehensive training on your new instrumentation and other hardware. We also provide customized options for different levels of testing and associated documentation packages (e.g., I/OQ,PQ), depending on our requirements.

Count on AES from start to finish:  Instrument and hardware specification, commissioning, design/fabrication of customized hardware, installation, qualification, training and support for as long as you need it.

Specific instrumentation and hardware solutions include:

  • Specification of instrumentation/equipment and compatible consumables, commissioning, design/fabrication
    – Bioreactor cell culture systems
    – Rocker cell expansion systems
    – Chromatography skids
    – Centrifugation apparatus
    – Filtration
    – Media/buffer vessels
    – Valve arrays
    – Compatible consumables
  • Custom cabinets
    For clean rooms or uncontrolled spaces
    Large and small footprints

System benefits

The system creates the ideal environment for a wide range of cell lines and organisms and supports high cell density processes. Typical applications include bacterial and mammalian product cell line systems. Bioreactors, available in sizes from 2L to XXL, can be used as a platform for solera, seed train, perfusion or N stage batch and fed-batch operations. bioreactor system

Space-saving design that’s easy to use

The system’s streamlined externally housed quad-pump saves you valuable work space whether in the lab or a commercial environment. And when part of an automated process, the industrial control layer enables remote process monitoring and control wherever network access is available. The control system’s intuitive user interface makes it easy for you to monitor and adjust all processes running on the AES Bioreactor Cell Culture System.

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YOU keep control

The control layer creates a modular system that easily integrates with an existing distributed control system (DCS) or as the start of a new site DCS. All online adjustments, historization and system information is presented remotely through your networked computer or local HMI. Control hardware and software are 21 CFR Part 11, GMP/GLP and ISA-88 compliant to satisfy regulatory requirements. Additionally, all control software code is transparent and open source, giving you the freedom to make modifications as needed. will also provide continued support, as needed, ervice

Technical Specifications

Size (W x H x D) ???
Voltage/Amperage ???

Vessel

Total volume 2100 mL
Working volume 1800 mL
Internal diameter (glass reactor) 105 mm
Overall height (glass reactor) 246 mm

Control

DCS Emerson DeltaV, DeltaV Discovery, PK Controller or Rockwell PlantPAX
Hardware protocol Ethernet/IP, DeviceNet, Profibus (others available upon request)
Interface Windows®-based PC or HMI
Software standard ISA-88.1

 

Process Instrumentation

Heat control Single-sided, heating blanket
pH control Mettler Toledo
DO control Polarographic or Optical Mettler Toledo
Pump control 3x integrated pumps for additions and harvest, Master Flex
Gas control 3x MFCs
Temperature probe PT100 RTD
Heat source Relay controlled heating jacket
O2 Brooks 2000 sccm
Mixed Air Brooks 2000 sccm
CO2 Brooks 2000 sccm
N2 Brooks 2000 sccm *additional cost applies
Agitation Direct Drive, 10-800 RPM

Specifications subject to change without notice.

Talk to an AES expert for more information on our instrumentation and hardware solutions