AES Bioprocess Controllers
Basic Mammalian Benchtop Bioprocess Controller
The Basic Mammalian Bioprocess Controller (BPC) is an innovative benchtop solution designed to optimize mammalian cell culture with precision and efficiency. This controller offers comprehensive control over critical parameters such as pH, dissolved oxygen (DO), temperature, and agitation, ensuring optimal growth conditions for mammalian cells. With its compact, ergonomic design, customizable hardware, and flexible operating ranges, the BPC is ideal for research, process development, and supporting scale-up processes. It is aligned with GMP standards and 21 CFR Part 11 compliance, providing a reliable and high-performance platform for biopharmaceutical applications.
Benefits of the Basic Mammalian Benchtop BPC System:
- Optimized Cell Culture Confitions: The controller provides precise control over critical parameters such as pH, dissolved oxygen, and temperature, ensuring optimal growth conditions for mammalian cell cultures.
- Flexible Integration: The system's open-architecture design allows for seamless integration with various equipment and instrumentation, enabling customization to meet specific bioprocessing requirements.
- Enhanced Process Control: With advanced automation features and real-time monitoring, the controller offers superior control over bioprocesses, improving consistency and productivity.
- Scalability: Suitable for a wide range of working volumes (2L to 15L), the system supports process development and scale-up, making it ideal for both small-scale research and larger biomanufacturing operations.
- Regulatory Compliance: Designed to align with GMP standards and 21 CFR Part 11 compliance, providing confidence in navigating stringent regulatory requirements.
Basic Mammalian Bioprocess Controller
Details & Technical Data
The Basic Mammalian Bioprocess Controller (BPC) offers a precisely controlled environment essential for the cultivation of mammalian cells, supporting applications from cell line development and process optimization to clinical manufacturing. Its adaptable design accommodates a wide range of cell types and culture conditions, providing precise control over critical parameters such as pH, dissolved oxygen, temperature, and agitation. Ideal for both suspension and adherent cultures, the BPC supports processes including cell culture expansion, monoclonal antibody production, vaccine production, and other biopharmaceutical applications.
- Working Volume Capacity: 2L to 15L
- pH Control: 2 – 12 pH
- Dissolved Oxygen (DO) Control: 0 – 100% Air Saturation ± 1% reading
- Temperature Control Range: 0 – 100°C ± 0.15°C
- Motor Speed Range: 0 – 600 RPM
- Agitation Direction Control: Bi-Directional
- Mass Flow Controllers (MFCs): 3 standard (Clean Compressed Air, O2, CO2) with an option for a 4th (N2)
- Flow Rate Range: 0.003 – 50 SLPM ± 3%
- On-Board Pumps: 4 pumps with Bi-Directional Stepper Motors
- Pump Speed Range: 0.2 – 200 RPM
- Pump Head Type: Peristaltic, Flip-Top Pump Heads
- Vessel Compatibility: Eppendorf, Sartorius, and Applikon vessels (Consult your sales rep for specific compatibility)
- Standard Automation & Control Offering: Rockwell™ software with Ethernet communication
- Enclosure Rating: IP-21 Available
- Power Requirements: 120 – 230 VAC, 50/60 Hz, 1200 Watts
More details are available in the technical brochure
Enhance your bioprocessing with AES Tubing Sets, designed for seamless integration with our Basic Mammalian Benchtop Bioprocess Controller (BPC) units. Featuring high-quality tubing options, including Platinum-Cured Silicone and Thermoplastic Elastomer, these sets deliver reliable performance in critical applications. Each component is assembled and packaged in an ISO 14644-1 Class 7 Clean Room environment, ensuring superior sterility and quality. The tubing sets are sterilized using Gamma Irradiation (27.5-45 kGy), providing unmatched safety and biocompatibility, compliant with USP Class VI and ISO 10993 standards. AES Tubing Sets guarantee exceptional durability and purity, making them the perfect choice for your bioprocessing needs.
- Material Composition: Platinum-cured Silicone, Thermoplastic Elastomer, Polycarbonate, Polypropylene, Nylon
- Environmental Requirement: ISO 14644-1 Class 7 Clean Room Environment
- Sterilization Method: Gamma Irradiation (27.5-45 kGy)
- Compatibility: Specifically designed for AES Basic Mammalian BPC units and your chosen compatible vessel
- Compliance: USP Class VI, ISO 10993
More details are available in the technical brochure.
The Basic Mammalian Benchtop Bioprocess Controller (BPC) is engineered to meet the stringent requirements of regulated environments. It is GMP compliant and can be configured to support 21 CFR Part 11 compliance, ensuring adherence to electronic records and signatures industry standards.
The AES Tubing Sets designed for the Basic Mammalian BPC are manufactured in an ISO 14644-1 Class 7 Clean Room environment, ensuring high standards of sterility and quality. These sets comply with USP Class VI and ISO 10993 standards, covering critical biocompatibility aspects. This ensures that the tubing sets meet biopharmaceutical applications’ essential safety and reliability requirements.
The Basic Mammalian Benchtop BPC System
(4) Integrated Pumps
Compatible Bioreactor Vessel
AES Tubing Set
Process Stop & On/Off Buttons
Gas Overlay & Sparge Connections
Agitation Connection, pH, DO, Biomass, CO2/O2, temp sensors, Remote I/Os
External Heating Connection
Why Choose AES for Your Mammalian Benchtop Bioprocess Controller?
Customizable for Your Bioprocess Needs
The Basic Mammalian Benchtop Bioprocess Controller can be tailored to meet the specific requirements of your bioprocess. Whether you need custom sizes, configurations, or features, we work closely with you to ensure this rocking bioreactor system aligns with your needs.
Seamless Integration for Your Lab or Facility
The Basic Mammalian Benchtop Bioprocess Controllwe is designed for seamless integration with your DCS. This compatibility allows for easy connection and communication with existing automation and control systems, enabling centralized monitoring and control of your operations.
Aftermarket Services & Training
Comprehensive aftermarket services and training is available to ensure you get the most out of your Mammalian Benchtop Bioprocess Controller. Our team provides ongoing support, maintenance, and training to keep your operations running efficiently and effectively.
Fabricated in the USA
All Bioprocess Controllers are manufactured in the USA, adhering to the highest standards of quality and precision. This ensures reliability and consistency in every unit, providing you with a dependable solution for your bioprocess needs.
Basic Mammalian Benchtop Bioprocess Controller Applications
Cell Culture
mAb | Vaccine Production | Antibodies | Recombinant Proteins | Cell-Based Meat
Gene
Therapy
AAV | Gene Replacement
Gene Editing | Oncolytic Viruses
Cell
Therapy
CAR-T Therapy | iPSC | MSC
Bioprocessing & Manufacturing
Media & Buffer Prep | Upstream Processing | Scale-up & Scale-down | Process Development
Frequently Asked Questions
Yes, the Basic Mammalian Benchtop BPC is highly customizable to accommodate specific process requirements. Our team collaborates closely with clients to tailor the system, optimizing it for unique cell culture and bioprocessing protocols.
The Basic Mammalian BPC offers more advanced gas control than the Basic Fermentation BPC. The Mammalian BPC features 3 to 4 Mass Flow Controllers (MFCs) that manage clean compressed air (CCA), oxygen (O2), carbon dioxide (CO2), and nitrogen (N2), with nitrogen being an optional configuration. On the other hand, the Fermentation BPC typically includes 1 to 2 MFCs, controlling only CCA and O2, with oxygen as an optional feature.
In addition to gas control, the agitation capabilities also differ. The Mammalian BPC is designed for gentler mixing, offering an agitation speed range of 0 to 600 RPM, ideal for sensitive mammalian cells. Conversely, the Fermentation BPC supports a broader range of agitation, from 0 to 1200 RPM, to accommodate the more vigorous mixing required for fermentation processes.
Absolutely. The Basic Mammalian Benchtop BPC integrates with Rockwell as a standard. However, our engineering team can customize the integration to seamlessly work with your preferred choice of DCS, ensuring compatibility and streamlined operation within your existing automation infrastructure.
Certainly! At AES, we conduct rigorous Factory Acceptance Testing (FAT) to guarantee that all equipment meets our stringent quality standards before it leaves our facility. In addition to FAT, our dedicated Global Service Team can oversee Site Acceptance Testing (SAT) to ensure seamless installation and operation at your site. For more detailed information, please visit our Aftermarket Service page.
Yes, in addition to detailed user manuals, we can provide comprehensive operator training sessions. Our training ensures your team can confidently operate and maintain our equipment, maximizing its performance and longevity.
Yes, we do. Our Global Service Team is unwaveringly dedicated to providing comprehensive aftermarket support to ensure your equipment continues to operate at peak performance. For any issues that cannot be resolved remotely, we guarantee on-site arrival within 48 hours. For more details, please visit our Aftermarket Service page.
Lead times vary depending on the complexity and customization requirements of the equipment. Our sales team can provide specific lead time estimates based on your project timeline and needs.
We can provide references upon request. These documents showcase our successful collaborations and the positive impact of our solutions on our clients’ operations.
Get a Bioprocess Controller that Meets Your Specific Bioprocess Today!
