Single-Use Mixing System
Precision Mixing for Biopharmaceutical Applications
The AES BioMix Single-Use Mixer (SUM) sets a new standard in precision mixing for biopharmaceutical manufacturing. Integrating advanced automation with a bottom-mounted magnetic drive agitator to ensure optimal process efficiency.
Designed to address the critical challenges of bioprocessing, the BioMix SUM enhances sterility and contamination control with a sealed, single-use system, eliminating cleaning requirements while maintaining high reproducibility.
With scalable volume options from 50L to 3000L and real-time process monitoring for pH, temperature, and conductivity, the BioMix streamlines media and buffer preparation, product formulation, and fill/finish operations-delivering consistent, high-quality results for both R&D and large-scale production.
Benefits of the BIOMIX Single-Use Mixer
Gentle, Uniform Mixing Without Compromise
Achieve fast, uniform, and repeatable mixing with a bottom-mounted magnetic drive agitator engineered to minimize shear stress. Ideal for delicate biologics and applications where gentle agitation is critical to product integrity.
Built-In Sterility That Simplifies Compliance
The sealed magnetic drive eliminates direct contact between the motor and fluid, drastically reducing contamination risks. Designed to meet GMP standards, the AES BioMix supports sterile processing with confidence.
Flexible Scale-Up That Grows With You
From benchtop R&D batches to large-scale manufacturing runs, the AES BioMix is available in a range of sizes (50 L to 3000 L) to seamlessly support your growth. Scale up or scale down with the same performance and process control.
Confident, Real-Time Decision-Making
Integrated single-use sensors provide real-time insights into pH, temperature, conductivity, and pressure. Maintain control of critical process parameters and ensure batch-to-batch consistency with built-in compliance support.
Less Maintenance. More Uptime.
Designed without mechanical seals or shafts, the BioMix minimizes wear and tear while eliminating cleaning validation requirements. Spend less time maintaining equipment and more time optimizing your process.
BIOMIX System Details & Technical Data
The AES BioMix Single-Use Mixer (SUM) is designed to meet the rigorous demands of modern bioprocessing, delivering precision, sterility, and scalability for media and buffer preparation, product formulation, and fill/finish operations. Featuring a bottom-mounted magnetic drive agitator and advanced automation, it ensures uniform mixing with minimal shear stress. With seamless integration of single-use bags, real-time process monitoring, and robust contamination control, the BioMix SUM supports diverse production needs—offering a reliable, efficient, and scalable solution for biopharmaceutical manufacturing.
Single-Use Mixer (SUM):
- Volume Options: 50 L to 3,000 L
- Mixing Technology: Bottom-Mounted Magnetic Drive Agitator for uniform mixing with minimal shear stress
Weight Measurement: (4) Integrated Load Cells with Real-Time Monitoring
Capacity:
50L & 100L SUM: 100 kg
200L SUM: 200 kg
1000L SUM: 1000 kg
2000L SUM: 2000 kg
3000L SUM: 3000 kg
Process Tolerance: 0.5%
Temperature Control: RTD Sensor (-50°C to +260°C) with ±2% accuracy
Process Analytics: Integrated real-time monitoring for pH (3-10 pH, ±0.15 accuracy), temperature, conductivity (100 µS/cm – 300 mS/cm), and pressure
More details are available in the technical brochure.
Ensure reliable, sterile fluid transfer with BioMix consumables, engineered for precision mixing in biopharmaceutical manufacturing. Designed to support a range of production needs, these pre-sterilized, ready-to-use components seamlessly integrate with the BIOMIX system, ensuring consistent performance, minimized contamination risks, and optimized workflow efficiency.
- BIOMIX Bags: The Biomix bags are specifically designed to be used with the Biomix Single-Use mixer, these bags maintain product integrity during mixing. The sterile, flexible containment options support various mixing volumes, which is ideal for sensitive applications.
More details are available in the technical brochure.
The BioMix System is engineered to meet the stringent requirements of regulated environments. It is GMP compliant and can be configured to support 21 CFR Part 11 compliance, ensuring adherence to electronic records and signatures industry standards.
Explore key features of The BIOMIX Single-Use Mixer
Bottom-mounted Magnetic Drive Agitator
Single-use Conductivity
Sensor
RTD Sensor
Single-use pH Sensor
(2) Peristaltic Pumps
(4) Integrated Load Cells
Drain Connection
Mixing Basin
(4) Casters with Brakes
E-Stop Button
Hand Rail
Why Choose AES for Your Single-Use Mixer?
Customizable for Your Bioprocess Needs
The AES BioMix Single-Use Mixer (SUM) is engineered to meet the specific demands of your bioprocessing workflows. Whether you require customizable volume options, seamless integration with existing control systems, or advanced process monitoring, our team collaborates with you to ensure optimal performance. Designed for efficiency, sterility, and precision, the BioMix SUM streamlines your mixing needs.
Seamless Integration for Your Lab or Facility
Our BioMix SUM seamlessly integrates with your existing bioprocessing infrastructure and preferred control systems. Its flexible design ensures compatibility with automation platforms, enabling real-time monitoring, precise data acquisition, and comprehensive process control. This integration enhances efficiency, consistency, and scalability, optimizing your biopharmaceutical workflows.
Aftermarket Services & Training
AES provides comprehensive support to help you maximize the performance of your BioMix SUM. From routine maintenance and troubleshooting to specialized operator training, our dedicated team ensures seamless operation, minimizing downtime and optimizing efficiency. With AES, you gain a reliable partner committed to the long-term success of your bioprocessing workflows.
Fabricated in the USA
Every AES BioMix SUM is proudly manufactured in the USA to meet the highest standards of quality, precision, and durability. Our systems are engineered for dependability, ensuring consistent results and long-lasting performance for your bioprocessing needs.
Think AES for Your Single-Use Mixing Solutions
BIOMIX SUM Applications
Media & Buffer Prep
- Large-Scale Media Preparation for Cell Cultures
- Buffer Preparation for Downstream Processes
- Fermentation Media Prep
- Support for mAbs Production
- Solutions for Cell and Gene Therapy Media Prep
Product Formulation
- Final Drug Product Formulation
- Personalized Therapy Batch Prep
- mAbs and Recombinant Protein Formulation
- Viral Vector and mRNA Therapeutic MixingViral Vector and mRNA Therapeutic Mixing
- Clinical Trial Batch Formulation
Fill/Finish Operations
- Bulk Drug Substance Prep for Filling
- Aseptic Fill/Finish Support
- Final Buffer Adjustments Pre-Fill
- Fill/Finish for mAbs and Biologics
- Multi-Product or Small-Batch Fill/Finish
Client spotlight
A partnership in Innovation
Frequently Asked Questions
Below are answers to some of the most common questions about the AES BioMix SUM. Whether you’re looking for technical specifications, scalability options, or insights into how this single-use mixer integrates into your bioprocess, we’ve got you covered. If you have any further questions, please don’t hesitate to contact our team.
The BioMix System supports flexible volume options ranging from 50L to 3000L, allowing seamless scalability from small-scale R&D to full-scale biomanufacturing.
The AES BioMix Single-Use Mixer is designed for high-precision biopharmaceutical manufacturing, offering advanced mixing capabilities for critical applications such as buffer and media preparation, product formulation, and fill-finish operations. With its bottom-mounted magnetic drive agitator, the system ensures thorough, uniform mixing while maintaining sterility, making it ideal for producing sterile injectable drugs, vaccines, biologic formulations, parenteral nutrition solutions, and cell culture media.
The system utilizes pre-sterilized, gamma-irradiated single-use bags and integrates single-use sensors to minimize contamination risks, ensuring a closed, aseptic mixing environment.
Yes, the BioMix is designed to support continuous bioprocessing and high-volume manufacturing, ensuring batch-to-batch consistency and efficiency. It can hold from 50L – 3000L.
The AES BioMix System offers seamless integration with the client’s preferred control system, ensuring compatibility with existing bioprocess automation platforms. This flexibility allows for real-time monitoring, data logging, and process optimization, enabling a streamlined and efficient workflow tailored to specific operational requirements.
At AES, we conduct rigorous Factory Acceptance Testing (FAT) to guarantee that all equipment meets our stringent quality standards before it leaves our facility. In addition to FAT, our dedicated Global Service Team can oversee Site Acceptance Testing (SAT) to ensure seamless installation and operation at your site. For more detailed information, please visit our Aftermarket Service page.
Yes, in addition to detailed user manuals, we can provide comprehensive operator training sessions. Our training ensures your team can confidently operate and maintain our equipment, maximizing its performance and longevity.
Yes, we do. Our Global Service Team is unwaveringly dedicated to providing comprehensive aftermarket support to ensure your equipment continues to operate at peak performance. For any issues that cannot be resolved remotely, we guarantee on-site arrival within 48 hours. For more details, please visit our Aftermarket Service page.
Lead times vary depending on the complexity and customization requirements of the equipment. Our sales team can provide specific lead time estimates based on your project timeline and needs.
We can provide references upon request. These documents showcase our successful collaborations and the positive impact of our solutions on our clients’ operations.
OPTIMIZE YOUR BIOPROCESS WITH HIGH-PERFORMANCE MIXING
Enhance every stage of your bioprocessing workflow with the AES BioMix SUM—a cutting-edge solution for precise, scalable, and sterile mixing. Whether for product formulation, buffer and media preparation, or fill-finish operations, our BioMix SUM ensures uniformity, stability, and efficiency in single-use bioprocessing. Our experts are ready to provide a customized solution tailored to your needs.
Complete the form to receive a custom quote and discover how our BioMix SUM can elevate your production efficiency.
