AES Tangential Filtration Flow (TFF) Systems
Streamline Your Filtration Process with
the Precision TFF Benchtop Unit
The Precision Benchtop Tangential Flow Filtration (TFF) Unit is engineered for high efficiency and adaptability, making it the ideal solution for ultrafiltration and diafiltration applications. With a robust control system offering real-time monitoring, intuitive user interfaces, and precise data logging, this unit enhances process control while integrating effortlessly into your existing bioprocess infrastructure. For monoclonal antibody production, recombinant proteins, or viral filtration, the Precision TFF Unit ensures consistent, high-quality results.
Designed to meet the rigorous demands of GMP-compliant environments, this compact unit offers automated pressure control, advanced bubble detection, and seamless integration into purification workflows. From process development to full-scale manufacturing, the Precision Benchtop TFF Unit delivers reliable performance to meet your filtration needs.
Benefits of the Precision TFF Benchtop Unit:
- Precise Filtration Control: Real-time control of pressure and flow rate, ensuring accurate product filtration. This enhances product yield and purity for protein purification and viral filtration.
- Enhanced Membrane Compatibility: Supports a range of membrane types and pore sizes, enabling efficient filtration for protein concentration, buffer exchange, and virus concentration.
- Advanced Bubble Detection: The integrated bubble detection system prevents air contamination, ensuring product safety and process consistency while reducing batch failure risks.
- Scalable Automation: With flexible integration into Rockwell™ infrastructure as the standard, this unit can be customized to work with your preferred control system, supporting future scalability for both small-scale and larger commercial operations.
- Compact & Space-Saving Design: Ideal for space-limited labs, the unit delivers powerful functionality while maintaining a minimal footprint, optimizing your workspace efficiency.
Precision TFF Benchtop Unit
Details & Technical Data
The Precision Benchtop TFF Unit optimizes tangential flow filtration processes with customizable control modes for ultrafiltration, diafiltration, and other separation applications. It integrates seamlessly into your bioprocessing infrastructure, offering enhanced filtration precision and efficiency across multiple biomolecule purification tasks. Its compact, user-friendly design is ideal for space-constrained labs while delivering high-performance filtration for protein concentration, virus concentration, and buffer exchange workflows.
- Pump Speed Range: 0.2 to 200 RPM, supported by bi-directional stepper motors for precise flow control.
- Flow Rate Capacity: Up to 340 mL/min, customizable with various tubing sizes (Max ID: 4.8 mm, L/S #25).
- Membrane Compatibility: Supports various membrane types for ultrafiltration and diafiltration processes.
- Pressure Range: 0 – 60 psi, monitored by a single-use pressure sensor with ±0.15 psi accuracy.
- Bubble Detection: An integrated bubble detection system prevents air contamination, ensuring process integrity.
- Automation & Control: Standard with Rockwell™ automation; customizable to your preferred control system.
- Power Requirements: 120 – 230 VAC, 50/60 Hz, 1200 Watts.
- Dimensions (H x W x D): 41.7 in x 41.3 in x 20.3 in.
More details are available in the technical brochure.
Ensure reliable Tangential Flow Filtration (TFF) workflows with AES precision consumables designed for efficient, sterile operations. Tailored for various filtration applications—including protein purification, viral concentration, and fluid management—these pre-assembled and sterilized components simplify setup and enhance performance.
- Flowpath Assembly: A pre-assembled, sterilized combination of the sample manifold and sample bags that ensures seamless integration and optimized fluid transfer across various filtration applications.
- Permeate Bag (5L): Sterilized and ready for use, ensuring secure and efficient permeate collection during filtration.
- (4) Buffer Bags (2L): Designed to support fluid management and consistent buffer exchange for reliable filtration processes.
- WFI Bag (5L): Sterilized for water-for-injection (WFI) applications, ensuring high purity and safe critical-process handling.
More details are available in the technical brochure.
The Precision Tangential Flow Filtration (TFF) Unit is engineered to meet the stringent requirements of regulated environments. It is GMP compliant and can be configured to support 21 CFR Part 11 compliance, ensuring adherence to electronic records and signatures industry standards.
Precision TFF Benchtop Unit
Feed Pump
Recirculation Pump
TMP Valve
Supply Bubble Detector
Recirculation Bubble Detector
Permeate Bubble Detector
Permeate Scale
Recirculation Scale
Recirculation Scale
TMP Box
WFI, Buffer, and Sample Bags
Flowpath Assembly
Your Preferred Filtration Membrane
Why Choose AES for Your Tangential Flow Filtration (TFF) Systems?
Customizable for Your Bioprocess Needs
The AES Precision TFF Unit is designed to meet the unique specifications of your bioprocess. Whether you require specific hardware configurations or seamless control system integration, we work with you to ensure the unit aligns with your purification and filtration processes, optimizing for efficiency and accuracy.
Seamless Integration for Your Lab or Facility
Our TFF systems integrate smoothly with your existing infrastructure or preferred control system. The flexibility of our design ensures easy communication with your automation setup, enabling precise monitoring, data acquisition, and control for a streamlined and productive workflow.
Aftermarket Services & Training
AES provides comprehensive support after purchase to ensure you get the most out of your TFF system. From maintenance and troubleshooting to operator training, our team is dedicated to keeping your operations running efficiently and reliably, reducing downtime and ensuring optimal performance.
Fabricated in the USA
Every AES TFF unit is proudly manufactured in the USA to meet the highest standards of quality and precision. Our systems are engineered to be robust and dependable, delivering consistent results for your bioprocessing needs.
Precision Tangential Flow Filtration (TFF) Benchtop Unit Applications
Protein Concentration
Monoclonal Antibody (mAb) Concentration
Enzyme Concentration
Recombinant Protein Concentration
Biosimilar Concentration
Gene Therapy
Viral Vector Filtration (AAV, Lentivirus)
Plasmid DNA Filtration
Viral Particle Filtration
Cell Therapy
Cell Harvesting
Cell Clarification
Exosome Concentration
Viral Filtration & Clearance
Virus Particle Removal
Viral Clearance for Biopharmaceuticals
Biomolecule Filtration & Separation
Plasmid DNA
Protein Filtration
Nucleic Acid Separation
Biomolecule Separation
Buffer
Exchange
Buffer Exchange for Downstream Processing
Preparation for Protein Purification
Sample Preparation Prior to Chromatography
Frequently Asked Questions
Below are answers to some of our most common questions about our Precision Tangential Flow Filtration TFF Benchtop Unit. Whether you’re looking for detailed specifications, customization options, or insights into how the system fits your process, we’ve got you covered. If you have any further questions, please don’t hesitate to contact our team.
The AES Precision TFF Unit is designed to support a wide range of filtration applications, including protein purification, viral concentration, and biomolecule separation. Whether for research or process development, it provides high reliability and flexibility across your filtration workflows.
The unit is highly customizable to fit your specific needs. It integrates seamlessly with Rockwell™ automation as standard, but we can customize it to your preferred control system. Additionally, the tubing, flowpath, and other components are configurable to ensure compatibility with your processes.
Yes! Our TFF unit supports manual, semi-automated, and fully automated filtration processes. You can begin with manual controls and easily upgrade to full automation as your bioprocessing requirements evolve, ensuring scalability with your facility’s needs.
Our unit features real-time monitoring and control of key parameters such as pressure, flow rates, and temperature. These capabilities allow you to adjust on the fly, helping to optimize your filtration process and improve both yield and product quality.
The TFF unit is equipped with real-time sensors for pressure, conductivity, and flow rate monitoring. This provides precise control over critical parameters, ensuring accurate and consistent results for each filtration cycle, no matter the complexity of the process.
The integrated, clamp-on bubble detection system safeguards your process by preventing air contamination in the flowpath. This feature protects your product and process integrity, ensuring optimal filtration performance and product purity.
Absolutely. The AES Precision TFF Unit is designed for ease of integration. Its compact and space-efficient design allows it to fit into various lab spaces, and our team provides full installation support. Plus, its user-friendly automation makes it easy for new and experienced users to operate.
Certainly! At AES, we conduct rigorous Factory Acceptance Testing (FAT) to guarantee that all equipment meets our stringent quality standards before it leaves our facility. In addition to FAT, our dedicated Global Service Team can oversee Site Acceptance Testing (SAT) to ensure seamless installation and operation at your site. For more detailed information, please visit our Aftermarket Service page.
Yes, in addition to detailed user manuals, we can provide comprehensive operator training sessions. Our training ensures your team can confidently operate and maintain our equipment, maximizing its performance and longevity.
Yes, we do. Our Global Service Team is unwaveringly dedicated to providing comprehensive aftermarket support to ensure your equipment continues to operate at peak performance. For any issues that cannot be resolved remotely, we guarantee on-site arrival within 48 hours. For more details, please visit our Aftermarket Service page.
Lead times vary depending on the complexity and customization requirements of the equipment. Our sales team can provide specific lead time estimates based on your project timeline and needs.
We can provide references upon request. These documents showcase our successful collaborations and the positive impact of our solutions on our clients’ operations.
Get Started with Your Custom TFF Solution Now
