Bulk Media & Buffer Preparation System
Achieve unparalleled precision, sterility, and scalability in high-volume media and buffer preparation with the AES OptiPrep System
The AES OptiPrep System sets the standard for media and buffer preparation, combining precision engineering with advanced automation to meet the rigorous demands of biopharmaceutical production.
Engineered with a deep understanding of bioprocessing challenges, the OptiPrep System ensures high sterility and contamination control, delivering unmatched efficiency and scalability in media and buffer batch sizes. This system streamlines operations, supporting consistent, high-quality production while maintaining the integrity and safety of your bioprocessing workflow.
Benefits of the OPTIFill fILL FINISH System
Unparalleled Precision
Achieve exceptional accuracy with advanced pump technology and flow sensors, ensuring precise control with a flow rate precision of ±6 mL/min at low flows, ±20 mL/min at higher flows, and a target volume accuracy of ±5%. This ensures reliable, consistent results across all media and buffer preparation processes.
Enhanced Contamination Control
Equipped with a Single-Use Mixers (SUM) and aseptic tubing sets, the OptiPrep System ensures sterility throughout media and buffer preparation, reducing contamination risks and maintaining product integrity.
Seamless Container Integration & Compatibility
With the ability to support your choice of container, including both bags and bottles, the OptiFill System integrates effortlessly into various bioprocessing workflows. This versatility ensures smooth operation and compatibility with both new and existing processes, providing reliable performance tailored to your production needs.
Flexible Scaling Capabilities
Capable of handling filling volumes ranging from 100 mL to 50 L, the automated system is designed to scale with your production needs, from small-scale clinical batches to large-scale commercial runs.
Single-Use Mixer for Enhanced Efficiency
Equipped with a Single-Use Mixer (SUM) that minimizes contamination risk while delivering consistent, homogenous mixing, maintaining product integrity throughout the cycle. This feature offers unparalleled operational flexibility, allowing seamless transitions between different production scales and products.
Advanced Automation & Control
Leverage the power of the Emerson DeltaV control system for seamless operation, or choose a control system that aligns with your facility. Real-time data collection, remote monitoring, and intelligent alarm systems enhance productivity and enable proactive process management, ensuring efficient and reliable operations.
OptiPRep System Details & Technical Data
The AES OptiPrep System is purpose-built to meet the rigorous demands of modern bioprocessing, delivering high precision, sterility, and scalability for bulk media and buffer preparation. Engineered with advanced automation and a user-centric design, it supports diverse production needs with seamless container integration, robust contamination control, and comprehensive monitoring capabilities to ensure consistent and efficient operations.
Liquid Handling Unit (LHU):
- Flow Rate Accuracy:
- ±6 mL/min for low-flow rates (0 – 300 mL/min)
- ±20 mL/min for higher-flow rates (1,000 – 10,000 mL/min)
- Pump Type: Peristaltic, Flip-Top
- Pump Speed Range: 0.2 – 410 RPM
- Pressure Sensors: 2 sensors (-0.7 to 7.5 psig)
- Flow Meter: Clamp-on, 6 – 3,000 mL/min range (for low-flow)
- Filling Volume Range: 100 mL – 50 L
- Target Filling Accuracy: ±5%
Single-Use Mixer (SUM):
- Volume Options: 50 L to 3,000 L
- Mixing Technology: Magnetic Levitation for uniform agitation
- Weight Measurement: Integrated load cells for real-time monitoring
- Temperature Control: RTD sensor, 20°C – 60°C ± 0.15°C
More details are available in the technical brochure.
Ensure seamless, sterile fluid transfer with AES OptiPrep consumables, designed for high precision and reliability in biopharmaceutical media and buffer preparation. Tailored for various production needs, these pre-assembled and sterilized components integrate effortlessly into your system, promoting consistent, efficient, and contamination-free operations.
- OptiPrep Tubing Set: The OptiFill Tubing Set ensures precise, aseptic fluid transfer by connecting the Single-Use Mixer (SUM), Liquid Handling Unit (LHU), and fill vessels. It’s engineered for flexible flow rate requirements, with high and low application options.
- SUM Bags: Specifically designed for the Single-Use Mixer, these bags maintain product integrity during mixing. The sterile, flexible containment options support various mixing volumes, which is ideal for sensitive applications.
- OptiPrep Containers (Bags or Bottles):
The system offers adaptable container options for various liquid volumes. Each container type is designed to meet specific storage requirements, including temperature compatibility down to -80°C, ensuring versatility for various bioprocessing needs.
More details are available in the technical brochure.
The OptiPrep System is engineered to meet the stringent requirements of regulated environments. It is GMP compliant and can be configured to support 21 CFR Part 11 compliance, ensuring adherence to electronic records and signatures industry standards.
Explore key features of The OptiPrep System
OptiFill Tubing Set
Touchscreen HMI
OptiFill Bags
(13) Pinch Valves
Bi-Directional Pump
E-Stop Button
E-Stop Button
Touchscreen HMI
Flow Meter
Liquid Sensor
(2) Pressure Sensors
Why Choose AES for Your Bulk media & Buffer preparation System?
Customizable for Your Bioprocess Needs
The AES OptiPrep System is designed to meet the unique specifications of your bioprocessing requirements. Whether you need specialized hardware configurations or seamless control system integration, we work closely with you to ensure the system aligns with your media and buffer preparation processes, enhancing efficiency, sterility, and accuracy.
Seamless Integration for Your Lab or Facility
Our media and buffer preparation systems integrate seamlessly with your existing infrastructure and preferred control systems. The flexible design ensures compatibility with your automation setup, enabling accurate monitoring, data acquisition, and comprehensive control for a streamlined, productive workflow.
Aftermarket Services & Training
AES provides robust support after purchase to help you maximize the potential of your media and buffer preparation system. From regular maintenance and troubleshooting to specialized operator training, our dedicated team ensures your operations run smoothly and reliably, minimizing downtime and optimizing system performance.
Fabricated in the USA
Every AES OptiPrep System is proudly manufactured in the USA to meet the highest standards of quality, precision, and durability. Our systems are engineered for dependability, ensuring consistent results and long-lasting performance for your bioprocessing needs.
Think AES for your Bulk Media & Buffer Preparation Needs—experience precision, scalability, and a partner committed to your success.
OptiPrep System Applications
Biopharmaceutical Production
Large-Scale Media Preparation for Cell Cultures,
Buffer Preparation for Downstream Processes,
Fermentation Media Prep,
Support for mAbs Production,
Solutions for Cell and Gene Therapy Media Prep
Quality
Control
Sterile Buffer Prep for Quality Testing,
Consistent Batch Preparation,
Media Preparation for Sterility: Testing, Endotoxin & Contaminant Testing
Bioprocess Scale-Up
& Development
Media & Buffer Preparation for Pilot-Scale,
Transitioning from R&D to Full-Scale Production,
Support for Continuous Bioprocessing Needs,
Media & Buffer Prep Supporting Single-Use OEM
Compliance & GMP Manufacturing
Preparation of GMP-grade Media & Buffers,
Sterile, FDA and EMA-compliant Processes,
Validated Solutions for Biomanufacturing,
Simplified Changeovers with Ready-to-Use Media
Clinical Research & Development
Media and Buffer Prep for Preclinical Studies,
Media and Buffer Prep for Clinical Trials,
Support for Vaccine Development and R&D,
High-Volume Media Preparation for Mammalian Cell Culture
Client spotlight
A partnership in Innovation
Frequently Asked Questions
Below are answers to some of our most common questions about the OptiPrep System. Whether you’re looking for detailed specifications, customization options, or insights into how this media and buffer preparation system integrates into your bioprocess, we’ve got you covered. If you have any further questions, please don’t hesitate to contact our team.
The AES OptiFill System offers a flexible filling volume range from 100 mL to 50 L, designed to meet the diverse needs of bioprocessing workflows and ensure seamless scalability.
The OptiPrep System is designed for flexibility, allowing the preparation of a wide range of media and buffer solutions commonly used in bioprocessing. Whether you’re working with standard culture media, specialized buffers for downstream processes, or customized formulations, the system ensures consistent, high-quality results.
Sterility is maintained through the use of single-use components, such as pre-assembled and sterilized tubing sets and mixing bags. The closed-system design minimizes the risk of contamination, ensuring that media and buffers are prepared in a controlled, sterile environment.
The OptiPrep System boasts a target volume accuracy of ±5%, providing precise control over your media and buffer volumes. This accuracy is critical for maintaining consistency and quality in bioprocessing applications.
Our system ensures flow rate accuracy of ±2% for flow rates between 300 and 3,000 mL/min and ±6 mL/min for flows up to 300 mL/min, ensuring reliable outcomes across various applications.
The OptiFill System is integrated with the Emerson DeltaV control system, with customization options available to suit your specific operational preferences.
The OptiPrep System is integrated with the Emerson DeltaV control system, with customization options available to suit your specific operational preferences.
Certainly! At AES, we conduct rigorous Factory Acceptance Testing (FAT) to guarantee that all equipment meets our stringent quality standards before it leaves our facility. In addition to FAT, our dedicated Global Service Team can oversee Site Acceptance Testing (SAT) to ensure seamless installation and operation at your site. For more detailed information, please visit our Aftermarket Service page.
Yes, in addition to detailed user manuals, we can provide comprehensive operator training sessions. Our training ensures your team can confidently operate and maintain our equipment, maximizing its performance and longevity.
Yes, we do. Our Global Service Team is unwaveringly dedicated to providing comprehensive aftermarket support to ensure your equipment continues to operate at peak performance. For any issues that cannot be resolved remotely, we guarantee on-site arrival within 48 hours. For more details, please visit our Aftermarket Service page.
Lead times vary depending on the complexity and customization requirements of the equipment. Our sales team can provide specific lead time estimates based on your project timeline and needs.
We can provide references upon request. These documents showcase our successful collaborations and the positive impact of our solutions on our clients’ operations.
START YOUR JOURNEY TO OPTIMAL MEDIA & BUFFER PREPARATION
Take the first step toward streamlining your bioprocessing workflow with the advanced AES OptiPrep System. Our experts are ready to guide you through a tailored solution that aligns with your operational needs. Complete the form to receive your custom quote and see how the OptiPrep System can elevate your media and buffer preparation processes.
